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Genitourin Med. 1993 Feb;69(1):44-6.

Lack of in vitro resistance of Candida albicans to ketoconazole, itraconazole and clotrimazole in women treated for recurrent vaginal candidiasis.

Author information

1
Department of Microbiology, St Michael's Hospital, University of Toronto, Ontario, Canada.

Abstract

OBJECTIVE:

To determine whether in vitro resistance of Candida albicans to the imidazoles (ketoconazole, clotrimazole and itraconazole) is associated with recurrence of candida vaginitis.

DESIGN:

Candida isolates were collected before, during and after treatment from women with recurrent vaginal candidiasis (> or = 4 episodes/year), randomised into two prospective studies: (1) 56 women treated with ketoconazole 400 mg/daily for 7 days; (2) 44 women randomised to receive itraconazole 200 mg orally, or clotrimazole 200 mg intravaginally, twice weekly for six months.

SETTING:

Women's Candida Clinic at St. Michael's Hospital, a University of Toronto teaching Hospital, Toronto, Ontario, Canada. MAIN OUTCOME, MEASURES: Isolates of yeasts recovered pre and post treatment were tested for significant changes in 50% inhibitory concentration (IC50). Resistance was defined as a greater than fourfold increase in baseline IC50 of post treatment isolates compared with pretreatment isolates.

RESULTS:

Over 250 strains of C albicans were tested and none showed development of resistance to any of the agents.

CONCLUSION:

Recurrence of vaginal candidiasis is not related to the development of drug resistance.

PMID:
8383096
PMCID:
PMC1195009
DOI:
10.1136/sti.69.1.44
[Indexed for MEDLINE]
Free PMC Article

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