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Antimicrob Agents Chemother. 1993 Jan;37(1):126-7.

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex.

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  • 1Department of Biochemistry, University of Leicester, United Kingdom.

Abstract

Binding of the quinolone drug norfloxacin to gyrase and DNA has been investigated. We have detected binding to gyrase-DNA complex but find no significant binding to either gyrase or DNA alone. Enzyme containing gyrase A protein with the mutation Ser-83 to Trp (conferring quinolone resistance) showed greatly reduced drug binding.

PMID:
8381633
PMCID:
PMC187618
[PubMed - indexed for MEDLINE]
Free PMC Article
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