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J Gen Virol. 1993 Feb;74 ( Pt 2):269-74.

Antagonistic modulation of human cytomegalovirus replication by transforming growth factor beta and basic fibroblastic growth factor.

Author information

1
Unité d'Immunologie Virale, Institut Pasteur, Paris, France.

Abstract

We studied the effect of two cytokines, basic fibroblastic growth factor (bFGF) and transforming growth factor beta (TGF-beta) on human cytomegalovirus (HCMV) replication in cultured human lung fibroblasts. We show that TGF-beta increases HCMV production, probably by a transcriptional mechanism, and that bFGF represses HCMV replication in a dose-dependent manner. These actions were antagonistic and the mechanisms involved were independent of the effects of these factors on cell DNA synthesis and proliferation.

PMID:
8381467
DOI:
10.1099/0022-1317-74-2-269
[Indexed for MEDLINE]

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