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Nature. 1993 Jan 28;361(6410):315-25.

Inositol trisphosphate and calcium signalling.

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1
AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK.

Abstract

Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.

PMID:
8381210
DOI:
10.1038/361315a0
[Indexed for MEDLINE]
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