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Trends Genet. 1993 Aug;9(8):269-74.

Myoblasts in pattern formation and gene therapy.

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Department of Pharmacology, Stanford University School of Medicine, CA 94305-5332.


The tissues of a multicellular animal are composed of diverse cell types arranged in a precisely organized pattern. Features unique to muscle allow an analysis of pattern formation and maintenance in mammals. The progeny of single cells can be taken full cycle from the animal to the culture dish and back to the animal where they fuse into mature myofibers of the host. These features not only facilitate the use of genetically engineered myoblasts in studies of pattern formation, but also in cell-mediated gene therapy: a novel mode of drug delivery for the treatment of muscle and nonmuscle diseases such as hemophilia, cardiac disease and cancer.

[Indexed for MEDLINE]

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