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Trends Genet. 1993 Jul;9(7):246-9.

Mutagenesis by 8-oxoguanine: an enemy within.

Author information

1
Department of Pharmacological Sciences, State University of New York, Stony Brook 11794-8651.

Abstract

The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatens genomic integrity: enzymes have evolved that protect prokaryotes and eukaryotes from the mutagenic effect of this ubiquitous lesion.

PMID:
8379000
[Indexed for MEDLINE]

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