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Chem Pharm Bull (Tokyo). 1993 Jul;41(7):1315-7.

Convenient syntheses of oligonucleotides linked to 5-deazaflavin coenzyme models at 3'-end. Incorporation of 5-deazaflavin to controlled pore glass (CPG) support.

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1
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

Abstract

Using CPG support linked with 5-deazaflavin, the 5-deazaflavin modified oligodeoxynucleotides at 3'-end(ODN-dF1) were synthesized. The thermal stability of the duplex of ODN-dF1 with its complement was higher than that of oligonucleotide linked to 5-deazaflavin at 5'-end internucleotide linkage.

PMID:
8375000
[Indexed for MEDLINE]

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