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Biosystems. 1993;30(1-3):161-71.

Recognition of genes in DNA sequence with ambiguities.

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School of Biology, Georgia Institute of Technology, Atlanta 30332-0230.


The search for genes in a newly sequenced DNA is a well known problem. Among other factors, the gene-searching process is hampered by a number of ambiguities which may remain unresolved experimentally for a long time. A computer method that is able to predict genes in a DNA sequence containing ambiguities has been developed, based on the non-homogeneous Markov chain technique. The reliability of the method has been tested using a set of sequences generated by a Monte-Carlo procedure and a set of 425 E. coli sequences with ambiguities introduced artificially.

[Indexed for MEDLINE]

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