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Biochem Biophys Res Commun. 1993 Sep 15;195(2):637-42.

Trans-membrane translocation of a myristylated protein amino terminus.

Author information

1
Istituto di Genetica Biochimica ed Evoluzionistica, Consiglio Nazionale delle Ricerche, Pavia, Italy.

Abstract

Hepatitis B virus surface protein variants are described, capable of translocating to the lumenal side of the endoplasmic reticulum membrane their myristylated N-termini, as revealed by the contestual modification of N-terminal, N-linked glycosylation sites. To our knowledge, this is the first example of transmembrane translocation of a preformed protein acyl adduct. The possible significance of this event for hepatitis B virus biology is discussed.

PMID:
8373403
DOI:
10.1006/bbrc.1993.2093
[Indexed for MEDLINE]

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