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J Virol. 1993 Oct;67(10):6273-7.

Two cis-acting signals control ribosomal frameshift between human T-cell leukemia virus type II gag and pro genes.

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Department of Molecular Genetics, Hebrew University, Hadassah Medical School, Jerusalem, Israel.


The open reading frame of the human T-cell leukemia virus type II pro gene is arranged at a -1 position relative to the gag gene. Synthesis of the Gag-Pro fusion polyprotein is facilitated by ribosomal frameshift into the reading frame of the pro gene. Cloning of a synthetic 41-bp oligonucleotide corresponding to the gag-pro junction within a heterologous gene (nef of human immunodeficiency virus type I) and mutation analysis revealed that two cis-acting signals, an adenosine residue stretch and a dyad symmetry sequence, flanking the UAA termination codon, are required for efficient ribosomal frameshifting between gag and pro. The stability of the stem-loop structure is crucial for frameshifting.

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