Format

Send to

Choose Destination
Eur J Immunol. 1993 Sep;23(9):2379-82.

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells.

Author information

1
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis 63110.

Abstract

Antigen receptor-directed suicide plays an important role in the elimination of potentially autoaggressive immature T cells during thymic differentiation. Here we demonstrated evidence for a second pathway of receptor-directed suicide in mature T cells that is missing in a mutant strain (gld) of mice with an "autoimmune" lymphoproliferative syndrome. The defect is evident within the gld activated T cell and does not require the presence of an antigen-presenting cell for its expression. Receptor-driven suicide is intact in immature T cells of animals with this mutation. These results support the significance of receptor-directed suicide in the mature T cell compartment and suggest that the immune system may use three independent pathways for regulating programmed cell death in shaping and controlling the immune response.

PMID:
8370416
DOI:
10.1002/eji.1830230951
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center