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Chemotherapy. 1993 Sep-Oct;39(5):297-301.

Pharmacokinetic profile of fosfomycin trometamol.

Author information

1
Department of Medical Microbiology, Kaptein W. Wilhelmsen og Frues, Bakteriologiske Institutt Rikshospitalet, University of Oslo, Norway.

Abstract

The pharmacokinetics of fosfomycin trometamol has been assessed in 12 healthy volunteers given oral doses of 2, 3, and 4 g of fosfomycin and 3 g intravenously of fosfomycin as fosfomycin sodium, all in the fasting state. The assay was microbiological (Proteus mirabilis ATCC 21100). There was a gradual rise in both peak serum concentrations and total area under the curve by rising oral doses, from 16.0 mg/l and 106.7 mg x h/l, after 2 g to 30.9 mg/l and 189.7 mg x h/l after 4 g respectively. The serum half-life was 4 h after the oral doses and 2.1 h after the intravenous dose. After the oral doses, the amounts excreted in urine in the active form ranged from 36 to 40% compared to 93% after the intravenous dose. The bioavailability was slightly below 40%. Concentrations in urine covers the usual urinary tract pathogens after oral doses of 2, 3, and 4 g.

PMID:
8370321
DOI:
10.1159/000239140
[Indexed for MEDLINE]

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