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Immunol Today. 1993 Jul;14(7):353-6.

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

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1
Dept of Immunology, University of Alberta, Edmonton, Canada.

Abstract

Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since TH1 cytokines compromise pregnancy and TH2 cytokines are produced at the maternal-fetal interface, we hypothesize that these TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens.

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PMID:
8363725
DOI:
10.1016/0167-5699(93)90235-D
[Indexed for MEDLINE]

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