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Pharmacol Ther. 1993 Feb-Mar;57(2-3):347-58.

Postmenopausal hot flushes and their management.

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Department of Pharmacology, School of Medicine, University of California, Los Angeles 90024.


Hot flushes are frequently incapacitating to the patient and the severe vasomotor disturbances may seriously impair normal daily life. This review attempts to provide an understanding of the pathophysiology of the hot flush as a basis for rationale therapy for each individual patient. The physiological mechanisms controlling body temperature are discussed briefly, and the changes in the system which precipitate the menopausal hot flush are detailed. The neuroendocrine events leading to the onset of the flushing syndrome are then considered. Finally, the therapeutic strategies which may be used in the management of the affected patient are discussed.

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