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Nature. 1993 Sep 2;365(6441):87-9.

Non-injection methods for the production of embryonic stem cell-embryo chimaeras.

Author information

1
Department of Molecular Embryology, Max-Planck Institut für Immunbiologie, Freiburg, Germany.

Abstract

The simple aggregation of pluripotent ES cells with morulae-stage embryos can result in viable chimaeras at a similar frequency to that of blastocyst injection. The savings in time and equipment inherent in the aggregation techniques, however, make this approach well worth considering.

PMID:
8361547
DOI:
10.1038/365087a0
[Indexed for MEDLINE]

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