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Nature. 1993 Sep 2;365(6441):27-32.

Disruption of the CNTF gene results in motor neuron degeneration.

Author information

1
Abteilung Neurochemie, Max-Planck-Institut für Psychiatrie, Martinsried, Germany.

Abstract

CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.

PMID:
8361533
DOI:
10.1038/365027a0
[Indexed for MEDLINE]
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