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J Chromatogr. 1993 Jul 23;643(1-2):369-78.

Liquid chromatographic analysis of antibacterial drug residues in food products of animal origin.

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Food and Drug Administration, Center for Veterinary Medicine, Beltsville, MD 20705.


This paper reviews recent developments in the liquid chromatographic (LC) methods of analysis for the residues of antibiotics (aminoglycosides, chloramphenicol, sulfonamides, tetracyclines, macrolides, beta-lactams, etc.) in food products of animal origin. The review also covers clean-up procedures, such as, ultrafiltration, liquid-liquid partition, solid-phase extraction, immunoaffinity, and matrix solid-phase dispersion, for use as extraction, deproteination, and concentration steps. The LC methods offer considerable potential for rapid automated analysis, and some may be used as direct screening for residues in meat and milk.

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