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Cephalalgia. 1993 Jun;13(3):166-71.

Placebo-controlled clinical trials with ergotamine in the acute treatment of migraine.

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  • 1Gothenburg Migraine Clinic, Sweden.

Abstract

Although oral ergotamine alone or in combination with caffeine is widely used for the acute treatment of migraine, there is little evidence that it is significantly more effective than placebo. There are no placebo-controlled data to support the use of aerosol or suppository formulations. In addition, the recommended doses of ergotamine cannot be justified. Each formulation of ergotamine now should be tested in clinical studies performed according to the IHS criteria for trial design and in migraine patients fulfilling the diagnostic criteria of the IHS. Until these clinical data are available, no clear recommendations can be given for the use of ergotamine in the acute treatment of migraine.

PMID:
8358774
[PubMed - indexed for MEDLINE]
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