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Br J Pharmacol. 1993 Jun;109(2):289-90.

Peripheral endotoxin induces hypothalamic immunoreactive interleukin-1 beta in the rat.

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Department of Clinical Biochemistry, School of Biomedical and Biomolecular Sciences, University of Newcastle, Newcastle upon Tyne.


Interleukin-1 (IL-1) is a polypeptide produced by a variety of cells and contributes to the general host response to inflammation. It displays a wide spectrum of inflammatory, metabolic, physiological, haematopoietic and immunological activities. Brain cells, including neurones, microglia, endothelial cells and astrocytes can all produce IL-1 beta in response to various physiological and pathological stimuli. In this report we show that peripherally administered endotoxin stimulates the appearance of immunoreactive IL-1 beta (IL-1 beta) in the rat hypothalamus as measured by an ultrasensitive, highly specific enzyme amplified immunometric assay for rat IL-1 beta.

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