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Curr Opin Genet Dev. 1993 Jun;3(3):491-8.

Genetic control of gastrulation in the mouse.

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Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106-4955.


In the past, understanding of the process of gastrulation in the mouse has primarily been based on morphological analyses. Recently, a number of molecules have been implicated in mesoderm induction and axis formation in Xenopus, and several of these exhibit unique patterns of expression during mouse gastrulation. These gene-expression data, together with fate mapping, ectopic expression experiments and mutational analysis, will now facilitate studies on the functional aspects of gastrulation in the mouse.

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