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Curr Opin Cell Biol. 1993 Jun;5(3):442-7.

Nuclear organization of pre-mRNA processing.

Author information

1
Cold Spring Harbor Laboratory, New York.

Abstract

Recent studies have suggested that small nuclear ribonucleoprotein particles (snRNPs), non-snRNP splicing factors, and several heterogeneous nuclear RNP proteins change their organization within the cell in response to transcriptional activity. Several of the RNA substrates with which these factors interact have been shown to localize in tracks that are associated with regions in which splicing factors are concentrated (nuclear speckles). It is now thought that pre-mRNA splicing may occur within these tracks.

PMID:
8352961
DOI:
10.1016/0955-0674(93)90009-f
[Indexed for MEDLINE]

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