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Proc Soc Exp Biol Med. 1993 Sep;203(4):405-17.

Regulated expression of the major histocompatibility complex class I genes.

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Department of Pathology, University of Connecticut Health Center, Farmington 06030.


The major histocompatibility complex (MHC) class I gene products are known to play a fundamental role in foreign antigen presentation to the cellular immune system. Much attention has been directed to the study of MHC class I gene expression as a means to understanding the processes by which MHC class I-mediated immune responses are regulated. Two areas of considerable interest have emerged, including regulation at the levels of transcriptional control and antigenic peptide-induced transport of MHC class I molecules. With an emphasis on these major areas of research, we review recent developments on the molecular and biochemical mediators and events of MHC class I gene regulation.

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