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J Rheumatol. 1993 Jun;20(6):950-2.

Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial.

Author information

1
Department of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

Abstract

OBJECTIVE:

To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX).

METHODS:

An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center.

RESULTS:

A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population.

CONCLUSIONS:

Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.

PMID:
8350329
[Indexed for MEDLINE]

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