Abstract
Bioassay-directed fractionation of the MeCOEt extract of Porella cordeana yielded drimenin [1] and aristolone [4], which were moderately toxic towards DNA-repair-deficient mutants of Saccharomyces cerevisiae. Three inactive sesquiterpenes, 7-ketoisodrimenin [2], 7-ketoisodrimenin-5-ene [3], and norpinguisanolide, were also obtained. Compounds 2 and 3 are new.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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CHO Cells
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Cricetinae
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DNA Repair / drug effects
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Leukemia P388 / pathology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Plants, Medicinal / chemistry*
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Saccharomyces cerevisiae / drug effects
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Saccharomyces cerevisiae / metabolism
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet