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FEBS Lett. 1993 Aug 2;327(3):307-10.

TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture.

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  • 1LOCE-Faculty of Medicine, Universit√© Libre de Bruxelles, Belgium.


We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.

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