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Curr Opin Immunol. 1993 Jun;5(3):418-22.

Sites of B-cell activation in vivo.

Author information

1
Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore 21201-1559.

Abstract

Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites, the periarteriolar lymphoid sheath-associated foci and germinal centers.

PMID:
8347301
DOI:
10.1016/0952-7915(93)90062-w
[Indexed for MEDLINE]

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