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Curr Opin Immunol. 1993 Jun;5(3):349-54.

The tyrosine kinase connection: how GPI-anchored proteins activate T cells.

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Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794-5215.


How can crosslinking of cell-surface glycosylphosphatidylinositol-anchored proteins activate T cells when the proteins do not reach the cytosol? Recent results show that glycosylphosphatidylinositol-anchored proteins associate with tyrosine kinases of the src family. Kinase activity is stimulated when glycosylphosphatidylinositol-anchored proteins are crosslinked. How the proteins are linked across the membrane, however, remains an intriguing mystery.

[Indexed for MEDLINE]

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