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Ugeskr Laeger. 1993 Jul 26;155(30):2354-6.

[2 cases of lymphangioleiomyomatosis treated by hormonal manipulation].

[Article in Danish]

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Medicinsk afdeling, Roskilde Amts Sygehus.


The course of disease in two women with bioptically verified lymphangioleiomyomatosis (LAM) is demonstrated. One was oestrogen- and progesterone-receptor negative, but responded promptly to hysterosalpingo-oophorectomy and has had no symptoms later. The other was receptor positive, but in spite of hysterosalpingo-oophorectomy and hormonal manipulation with tamoxifen and medroxyprogesterone, has had a complicated course of the disease with symptoms for ten years. LAM is a hormone dependent disease, but our knowledge is still incomplete. Hormonal manipulation should be tried in receptor positive as well as negative patients. Tamoxifen seems to have deleterious effects on the course of disease.

[Indexed for MEDLINE]

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