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Infect Dis Clin North Am. 1993 Jun;7(2):425-33.

Detection of methicillin-resistant staphylococci.

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Division of Infectious Diseases, San Francisco General Hospital, California.


Susceptibility tests commonly used in the clinical laboratory for detection of methicillin-resistant strains of staphylococci are discussed. The biochemical and genetic basis of methicillin resistance, including heterogeneous expression of resistance, is summarized. The conditions that can affect results of disk diffusion, broth dilution, and agar screen tests and sensitivity and specificity of these tests are reviewed. DNA detection methodologies, which, with their greater accuracy, may replace susceptibility testing, also are discussed.

[Indexed for MEDLINE]

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