Send to

Choose Destination
J Cardiovasc Surg (Torino). 1993 Jun;34(3):259-61.

Tissue-type plasminogen activator (t-PA) lysis of aortic and mitral valve thrombosis.

Author information

Department of Thoracic and Cardiovascular Surgery, Hokushin General Hospital, Nagano, Japan.


Valve thrombosis is one of the most serious complications after prosthetic valve replacement. We report the use of tissue-type plasminogen activator (t-PA) in the treatment of a patient with thrombosed aortic and mitral valves. Thrombolysis resulted in immediate hemodynamic improvement and resolution of congestive heart failure, thereby avoiding surgical intervention. Based on our experience, thrombolysis with t-PA is an effective alternative in the treatment of thrombosed prosthetic valves.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center