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JAMA. 1993 Aug 18;270(7):850-3.

Topical anesthesia during circumcision in newborn infants.

Author information

1
Division of Nursing Research, McGill University-Montreal Children's Hospital, Quebec, Canada.

Erratum in

  • JAMA 1994 Jan 26;271(4):274.

Abstract

OBJECTIVE:

To determine the efficacy of topical anesthetic cream, eutectic mixture of local anesthetics (EMLA), in alleviating pain from neonatal circumcision.

DESIGN:

Randomized, controlled trial.

SETTING:

Normal newborn nursery in a university teaching hospital.

PATIENTS:

Twenty-seven newborn, full-term male neonates, aged 1 to 3 days.

OUTCOME MEASURES:

Heart rate, transcutaneous oxygen saturation, facial activity, and crying.

RESULTS:

Compared with baseline, all newborns experienced pain as evidenced by increased heart rate of an average of 40 beats per minute (F [8, 25] = 14.12; P < .0001), decreased oxygen saturation of 3% (F [8, 25] = 15.02; P < .0001), and more facial actions indicative of pain (F [8, 25] = 5.25; P < .002) during all phases of the procedure. Compared with placebo, EMLA significantly attenuated the pain response as shown by lower heart rate of an average of 25 beats per minute (F [1, 25] = 14.92; P < .001), higher oxygen saturation of 5%, particularly during the clamping and lysis phases (F [1, 25] = 19.83; P < .0001), 20% less facial activity (F [1, 25] = 12.01; P < .002), and 15% less crying during the clamping, Gomco clamp application, and incision of the foreskin. There were no differences between groups in the spectral crying parameters.

CONCLUSIONS:

Circumcision procedure produces pain responses that EMLA diminishes. Thus, EMLA may be a useful agent for pain management in neonatal circumcision.

PMID:
8340985
[Indexed for MEDLINE]

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