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ORL J Otorhinolaryngol Relat Spec. 1993 Jul-Aug;55(4):208-10.

Expression of GAP-43 in growing efferent fibers during cochlear development.

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Departamento de Ciencias Morfológicas, Facultad de Medicina, Universidad Complutense, Madrid, España.


The development of olivocochlear efferent fibers has been studied by means of the immunocytochemical detection of the growth-associated protein GAP-43. This study has been carried out in pre- and postnatal, developing, pigmented rats. Results indicate that olivocochlear efferents reach the developing auditory epithelium from embryonic day 18 on. GAP-43-like immunoreactivity persists in the organ of Corti until the beginning of the second postnatal month. The relationships between the expression of GAP-43 in olivocochlear efferent fibers and other plasticity-related phenomena are discussed.

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