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J Neurol Sci. 1993 Jun;116(2):220-6.

4-Aminopyridine induces functional improvement in multiple sclerosis patients: a neurophysiological study.

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Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.


This study reports on the neurophysiological measurements that were performed in the context of a randomized, double-blind, placebo-controlled, cross-over study with intravenously administered 4-aminopyridine (4-AP) in 70 patients with definite multiple sclerosis (MS). A beneficial effect of 4-AP was found for both visual evoked response and eye movement registration parameters. This study extends the experimental data obtained on animal nerve fibers, showing that 4-AP can improve impulse conduction in demyelinated nerve, to clinical data which indicate that 4-AP induces an objective improvement in the central nervous system function in MS-patients. It thereby also provides a theoretical basis for clinical efficacy of 4-AP in MS.

[Indexed for MEDLINE]

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