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Dev Med Child Neurol. 1993 Aug;35(8):661-74.

Mental and behavioural deterioration of children with epilepsy and CSWS: acquired epileptic frontal syndrome.

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Service de P├ędiatrie, CHUV, Lausanne, Switzerland.


Four children with 'epilepsy and continuous spike-wave sleep' syndrome and mental and behavioural regression were followed prospectively with neuropsychological tests, behavioural questionnaires and sleep EEG performed at regular intervals between 1 1/2 and four years of age. The children showed a pattern of behavioural and cognitive disturbances similar to that found in some developmental autistic-like disorders, but also in adult frontal syndrome. Deterioration was probably due to an unusual long-standing epileptic dysfunction involving the frontal lobes. The process is potentially reversible and seems to be the same as postulated for acquired epileptic aphasia, but in a different localization.

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