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Am J Obstet Gynecol. 1993 Jul;169(1):175-8.

Bacterial vaginosis and prematurity in Indonesia: association in early and late pregnancy.

Author information

1
Division of Sexually Transmitted Diseases/Human Immunodeficiency Virus Prevention, Centers for Disease Control, Atlanta, GA 30333.

Abstract

OBJECTIVE:

Our objective was to examine the association between preterm delivery and bacterial vaginosis in early and late pregnancy.

STUDY DESIGN:

We evaluated 490 pregnant women at three hospitals in Jakarta, Indonesia, for bacterial vaginosis at 16 to 20 weeks' and 28 to 32 weeks' gestation and observed them through delivery.

RESULTS:

We found significant associations between preterm delivery (gestational age < 37 weeks) and bacterial vaginosis diagnosed at 16 to 20 weeks' gestation (odds ratio 2.0, 95% confidence interval 1.0 to 3.9) but not with bacterial vaginosis diagnosed at 28 to 32 weeks' gestation (odds ratio 1.5, 95% confidence interval 0.7 to 3.0). The rates of preterm delivery were almost doubled for women who had bacterial vaginosis in early pregnancy (20.5%) as compared with women who had bacterial vaginosis only in late pregnancy (10.7%).

CONCLUSION:

Only bacterial vaginosis diagnosed early in the second trimester of pregnancy plays a major role as a risk factor for preterm delivery.

PMID:
8333449
DOI:
10.1016/0002-9378(93)90157-e
[Indexed for MEDLINE]

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