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Nature. 1993 Jul 29;364(6436):401-6.

Transcriptional antitermination.

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1
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada.

Abstract

Antiterminator proteins control gene expression by recognizing control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream. The N protein of bacteriophage lambda recognizes a sequence in the nascent RNA, and modifies RNA polymerase by catalysing the formation of a stable ribonucleoprotein complex on its surface, whereas the lambda Q protein recognizes a sequence in the DNA. These mechanisms of antitermination in lambda provide models for analysing antitermination in viruses such as HIV-1 and in eukaryotic genes.

PMID:
8332211
DOI:
10.1038/364401a0
[Indexed for MEDLINE]
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