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J Occup Med. 1993 Jun;35(6):574-6.

Measuring male reproductive hormones for occupational field studies.

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National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226-1998.


As part of our longitudinal study of unexposed workers, we drew blood samples and analyzed the individual endocrine profiles for 45 men. The blood collection was between 8 AM and 8 PM, and three blood samples were drawn 20 minutes apart on three occasions during the course of the study (June, October, and February). Serum concentrations of follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin were determined. A component of variance model was used to estimate variability between the 20-minute blood draws. Statistical power analysis using this component showed that three blood draws provide a marginal improvement over a single blood draw in detecting population shifts. Also, if the prospect of three blood draws reduces subject participation by 10 to 20%, the increase in power would be negated.

[Indexed for MEDLINE]

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