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J Autism Dev Disord. 1993 Jun;23(2):323-39.

A prevalence study of autism in tuberous sclerosis.

Author information

1
Section of Child & Adolescent Psychiatry, University of Oxford, Park Hospital for Children, Headington, England.

Abstract

An estimate of the prevalence of autism in tuberous sclerosis (TSC) was made by interviewing the parents of 21 children between ages 3 and 11 ascertained during a previous population study of the condition in the West of Scotland. Five of the children (24%) were rated autistic and a further four (19%), all of whom were girls, had socially impaired behavior categorized as pervasive developmental disorder, without fulfilling all the DSM-III-R criteria for autism. One further boy had disruptive attention-seeking behavior that had excluded him from his normal school. The estimated prevalence from this study of autism in TSC is 1 in 4 children in general, and 1 in 2 of those with mental retardation. Tuberous sclerosis could be a significant cause of autism and pervasive developmental disorders, particularly in girls.

PMID:
8331050
DOI:
10.1007/bf01046223
[Indexed for MEDLINE]

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