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Clin Chem. 1993 Jul;39(7):1444-5.

Transferrin allelic variants may cause false positives in the detection of cerebrospinal fluid fistulae.

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Department of Pathology, University of Pittsburgh School of Medicine, PA 15213-2538.


Variations in either the polypeptide sequence or the carbohydrate moieties of transferrin may result in altered electrophoretic mobility of this molecule. We report a case of an allelic (polypeptide) variant of transferrin with mobility similar to that of the beta 2 (sialic acid-depleted) transferrin found in cerebrospinal fluid (CSF) and a few other body fluids. Allelic variation and other transferrin anomalies may be mistaken for the CSF isoform, resulting in false diagnoses of CSF fistulae.

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