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Biol Neonate. 1993;63(3):157-62.

Reduced secretion of interleukin-1 and tumor necrosis factor-alpha by neonatal monocytes.

Author information

1
Department of Pediatrics, University of Göttingen, FRG.

Abstract

Monocytes were isolated from peripheral blood of preterm and term newborn infants and adult controls, and their capacity to secrete the inflammatory mediators interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) was investigated. Lipopolysaccharide (LPS)-stimulated neonatal monocytes secreted significantly less IL-1 (median: 1.1 U/ml) than monocytes from adult controls (median: 7.3 U/ml). In addition TNF-alpha production by LPS-stimulated neonatal monocytes (median: 610 pg/ml) was significantly lower when compared with controls (median: 2230 pg/ml). Our data provide evidence that neonatal monocytes have a profoundly impaired cytokine secretion.

PMID:
8324095
DOI:
10.1159/000243926
[Indexed for MEDLINE]

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