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Biochem Biophys Res Commun. 1993 Jun 30;193(3):1184-90.

DNA methylation in folate deficiency: use of CpG methylase.

Author information

1
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37212.

Abstract

Folate deficiency produces a marked decrease in the ratio of S-adenosylmethionine to S-adenosylhomocysteine. This ratio regulates the activity of many cellular methylation reactions including that of DNA. We used bacterial CpG methylase to evaluate the effect of folate deficiency on methylation of DNA from livers of weanling rats fed an amino acid-defined folate deficient diet. After 4 weeks, liver DNA from deficient animals was undermethylated compared with DNA from pair-fed control animals.

PMID:
8323540
DOI:
10.1006/bbrc.1993.1750
[Indexed for MEDLINE]

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