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Arch Intern Med. 1993 Jul 12;153(13):1595-601.

Preventing restenosis with fish oils following coronary angioplasty. A meta-analysis.

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1
Department of Medicine, Medical College of Wisconsin, Milwaukee.

Abstract

BACKGROUND:

No medical therapy has been shown to reduce the rate of restenosis following percutaneous transluminal coronary angioplasty. We examined the existing evidence for the use of omega-3 fatty acids in this capacity with the tool of meta-analysis.

METHODS:

A computerized search and a bibliographic review of published articles were performed. Abstracts were identified through journals, Index Medicus, and an unpublished listing of recent requests for fish oil for experimental use. All English-language randomized clinical trials with available reports were included in the analysis. The quality, design differences, and outcomes were evaluated for each study.

RESULTS:

For four studies that used angiography to define coronary restenosis, the absolute difference in restenosis rates between treatment and control groups was 13.9% (95% confidence interval [CI], 3.2% to 24.5%). Furthermore, regression analysis revealed a positive linear relationship between the dose of omega-3 fatty acids used and the absolute difference in restenosis rates (r = .99, P < .03). When three studies that used stress testing as a means of determining restenosis rates were added to the four studies that used angiography, the risk difference was 5.1% (95% CI, -3.8% to 13.9%).

CONCLUSIONS:

Restenosis after coronary angioplasty is reduced by supplemental fish oils, and the extent of the observed benefit may be dependent on the dose of omega-3 fatty acids used.

Comment in

  • ACP J Club. 1994 Jan-Feb;120 Suppl 1:8-10.
PMID:
8323422
[Indexed for MEDLINE]
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