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Nihon Rinsho. 1993 Jun;51(6):1540-7.

[Physiological and pathophysiological role of endothelin-endothelin receptors system in cardiovascular system].

[Article in Japanese]

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2nd Department of Internal Medicine, Tokyo Medical and Dental University.


Since the discovery of a potent endothelium-derived vasoconstrictor peptide, termed endothelin (ET) in 1988, recent studies using molecular biology technique have revealed the existence of ET isopeptides (ET-1, ET-2, ET-3) and receptor subtypes (ETA, ETB). In cardiovascular system, ET family plays important roles not only in regulation of vascular tonus as a vasoconstrictor, but also in cardiovascular remodeling as a growth factor. Development and application of antagonists selective for ETA and ETB receptor and inhibitor of ET-converting enzyme should elucidate pathophysiological roles of ET family and its receptors in cardiovascular diseases.

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