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FEBS Lett. 1993 Jul 5;325(3):215-9.

Two sites in the third inner loop of the dopamine D2 receptor are involved in functional G protein-mediated coupling to adenylate cyclase.

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Theodor-Boveri-Institut für Biowissenschaften, Physiologische Chemie I, Universität Würzburg, Germany.


Synthetic peptides, corresponding to the amino acid sequences of the N- and C-terminal parts of the 3rd intracellular loop of the dopamine D2 receptor, attenuate dopaminergic adenylate cyclase inhibition in membranes. Both peptides also activate directly GTPase activity in membranes. We suggest a functional model for G(i)-coupled receptors where two sites in the 3rd inner loop compose the links for the receptor-G protein interaction thus providing the tools for a selective and adjustable response. Functional coupling was not affected by a peptide representing the insert in the long form of the dopamine D2 receptor (D2(long)). The selectivity pattern of conventional G protein-linked receptors also sheds some light on the recently observed interaction of beta-amyloid protein precursor (APP) complexes with G proteins.

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