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Curr Genet. 1993 May-Jun;23(5-6):392-6.

Phenotypic identification of amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae.

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Department of Biological Sciences, University of Cincinnati, OH 45221-0006.


Primary gene amplification, i.e., mutation from one gene copy to multiple gene copies per genome, is important in genomic evolution, as a means of producing anti-cancer drug resistance, and is associated with the progression of tumor malignancy. Primary amplification has not been studied in normal eukaryotic cells because amplifications are extremely rare in these cells. A system has been developed to phenotypically identify co-amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae and 21 independent spontaneous amplifications have been isolated.

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