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AIDS. 1993 May;7(5):625-31.

T-cell antigen receptor V beta subsets are not preferentially deleted in AIDS.

Author information

1
Division of Allergy-Immunology, Cornell University Medical College, New York, New York 10021.

Abstract

OBJECTIVE:

Evidence for an HIV-1-associated superantigen (SAg) has been presented. Here we test whether targeted T cells are preferentially depleted in AIDS.

DESIGN:

The T cell antigen receptor (TCR) V beta repertoire was compared in 44 HIV+ hemophiliac patients and in 27 controls.

METHODS:

Eleven TCR V gene-specific monoclonal antibodies (MAb), representing approximately one-third of the V beta repertoire were used to measure T-cell numbers expressing V beta and V alpha genes in both the CD4 and the CD8 subsets by two-color immunofluorescence.

RESULTS:

The percentage of T cells expressing these V genes could be accurately quantitated in both the CD4 and the CD8 T-cell populations and at various clinical stages of disease progression. No preferential deletion of any particular V gene subsets was detected.

CONCLUSION:

CD4 T-cell depletion in AIDS is not V beta-selective.

[Indexed for MEDLINE]

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