Abstract
The preservation of vascular integrity and blood flow is essential for vital functions. The dynamic equilibrium between bleeding and clotting can be set awry by stimulation of the inflammatory or immune response or by unchecked activation of the coagulation or fibrinolytic systems. It is through greater understanding of the complex interplay between these pathways that we are able to develop agents that can, with increasing specificity, manipulate coagulation and restore hemostasis.
MeSH terms
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Blood Coagulation Disorders / diagnosis
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Blood Coagulation Disorders / drug therapy
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Blood Coagulation Disorders / physiopathology*
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Critical Care*
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Disseminated Intravascular Coagulation / diagnosis
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Disseminated Intravascular Coagulation / drug therapy
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Disseminated Intravascular Coagulation / physiopathology
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Heparin / adverse effects
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Humans
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Purpura, Thrombotic Thrombocytopenic / diagnosis
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Purpura, Thrombotic Thrombocytopenic / drug therapy
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Purpura, Thrombotic Thrombocytopenic / physiopathology
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Thrombocytopenia / chemically induced