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Gut. 1993;34(2 Suppl):S106.

Recombinant alpha interferon for chronic hepatitis B in anti-HIV positive patients receiving zidovudine.

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1
Service d'Hépatologie, Hôpital Beaujon, Clichy, France.

Abstract

In this pilot study of the effects of interferon alfa in 10 anti-HIV positive, chronic hepatitis B patients treated with zidovudine (AZT), tolerance to interferon was good and similar to that in anti-HIV negative patients. After treatment, the HIV stage and CD4 lymphocyte count were unchanged. In two patients hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg) disappeared and the serum alanine aminotransferase (ALT) returned to normal; loss of hepatitis B surface antigen (HBsAg) with absence of histopathological activity was observed after treatment in one of these patients. These preliminary results need to be confirmed by a larger study.

PMID:
8314471
PMCID:
PMC1374027
[Indexed for MEDLINE]
Free PMC Article
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