Intraventricular alpha interferon therapy for Rasmussen's syndrome

B L Maria; D M Ringdahl; J P Mickle; L J Smith; P D Reuman; R L Gilmore; W E Drane; R G Quisling

Intraventricular alpha interferon therapy for Rasmussen's syndrome

Can J Neurol Sci. 1993 Nov;20(4):333-6.

Authors

B L Maria¹, D M Ringdahl, J P Mickle, L J Smith, P D Reuman, R L Gilmore, W E Drane, R G Quisling

Affiliation

¹ Division of Pediatric Neurology, University of Florida College of Medicine, Gainesville 32610-0296.

PMID: 8313251

Abstract

A 4-year-old boy developed Rasmussen's syndrome and was treated with alpha interferon intraventricularly. An improvement in the epileptic and neurologic syndrome was noted for several weeks following interferon. No adverse side effects were encountered. Since hemispherectomy is the only established therapy in Rasmussen's Syndrome, further studies are needed to establish if intraventricular alpha interferon may halt the clinical progression of the syndrome.

Publication types

Case Reports

MeSH terms

Atrophy / diagnostic imaging
Atrophy / drug therapy
Atrophy / pathology
Brain / diagnostic imaging
Brain / pathology
Child
Encephalitis / diagnostic imaging
Encephalitis / drug therapy*
Encephalitis / pathology
Epilepsy / diagnostic imaging
Epilepsy / drug therapy*
Epilepsy / pathology
Humans
Injections, Intraventricular
Interferon Type I / administration & dosage
Interferon Type I / adverse effects
Interferon Type I / therapeutic use*
Magnetic Resonance Imaging
Male
Recombinant Proteins
Syndrome
Tomography, Emission-Computed, Single-Photon

Substances

Interferon Type I
Recombinant Proteins