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Clin Investig. 1993 Nov;71(11):918-23.

Prognostic factors in multiple myeloma: role of beta 2-microglobulin and thymidine kinase.

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Institut für Klinische Chemie, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.


Serum beta 2-microglobulin, serum thymidine kinase, and commonly used prognostic parameters were investigated for their prognostic value in a well-defined group of patients with multiple myeloma (n = 207). Multivariate analysis showed hemoglobin to be the parameter of strongest prognostic value. Only albumin, serum beta 2-microglobulin and serum thymidine kinase added further prognostic information. When tested for efficiency in recognizing patients with poor (average survival time < 1 year) and good (average survival time > 5 years) prognosis, serum beta 2-microglobulin was best (80%), followed by total urinary protein (78%), hemoglobin (76%), and albumin (75%).

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